Screening for new metabolites and Strain development
Screening for new metabolites and Strain development: Azharul Islam Shovon, B.Sc, Biochemistry and Molecular Biology, NSTU Screening: The use of highly selective procedures to allow the detection & isolation of only those microorganisms which are of interest from among a large microbial population. It is very time consuming and expensive process. For example, Eli Lilly & Co. Ltd discovered three species of antibiotic producing organisms in a span of 10 years and after screening 4,00,000 organisms. Although there are many screening techniques, all of them are generally grouped into two broad categories. They are: 1. Primary screening, and 2. Secondary screening. Primary Screening: Primary screening allows the detection & isolation of microorganisms that possess potentially interesting industrial application. Secondary Screening: Secondary screening allows further sorting out of microorganisms obtained from PS having real value for industrial processes and discarding